The Zodiac is a weapon manufactured by Megacorp in Ratchet & Clank: Going Commando. It fires a single charge that instantly annihilates all enemies within sight in the player's camera. The Zodiac is available for 1,500,000 bolts upon returning to the flying lab (now the Thugs-4-Less Prison) on Aranos. Unlike most other weapons in the game, it cannot be upgraded in any way. The Zodiac is a wrist-mounted orange weapon with small, blue lightning generators at the front, from which its blast is fired. When fired, it opens and charges up for a brief moment before the entire screen goes completely blank, after which every enemy is destroyed.
The Zodiac is an immensely powerful weapon against all non-boss enemies, capable of even slaying an Arctic leviathan in a single hit, but does little damage in comparison to bosses. Its ammunition is limited and pricey at 10,000 bolts each, though it can be found in ammo crates. Ultimately, the player is likely to have far more cost efficient ways to destroy enemies by the time they can afford the Zodiac, and normal enemies are not likely to pose a threat. The RYNO II is a far better purchase, as its ammunition is less expensive, while it is just as powerful against normal enemies and far stronger against bosses.
It is recommended to break ammo crates instead to pick up ammo for the weapon, as one crate can replenish 1 (2 in challenge mode) out of 4 charges, rather than buying ammo at a Megacorp vendor.
Behind the scenes
The Zodiac was more specifically referred to as the Zodiac Mk.II. This is because the original "Zodiac" weapon was in Insomniac Games' first game, Disruptor, which also wiped out enemies within sight.